{"id":1611,"date":"2020-03-13T11:40:05","date_gmt":"2020-03-13T11:40:05","guid":{"rendered":"http:\/\/ouman.eu\/?p=1611"},"modified":"2020-03-13T11:40:05","modified_gmt":"2020-03-13T11:40:05","slug":"%e3%80%8a%e8%87%aa%e7%84%b6%e3%80%8b%e6%9d%82%e5%bf%97%e6%b3%84%e5%af%86%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e7%9a%84%e5%8f%91%e6%ba%90%e5%9c%b0","status":"publish","type":"post","link":"https:\/\/ouman.eu\/?p=1611","title":{"rendered":"\u300a\u81ea\u7136\u300b\u6742\u5fd7\u6cc4\u5bc6\u65b0\u51a0\u75c5\u6bd2\u7684\u53d1\u6e90\u5730"},"content":{"rendered":"\n\n\n
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\"IMG_1012.JPG\"<\/p>\n

\u53ef\u591a\u6570\u7684\u56fd\u4eba\u6ca1\u90a3\u4e48\u5feb\u5065\u5fd8\uff0c\u6709\u4eba\u627e\u51fa\u4e86\u5a92\u4f53\u62a5\u9053\uff1a\u201c\u7f8e\u9996\u4f8b\u786e\u8bca\u7684\u201c\u96f6\u53f7\u60a3\u8005\u201d\u662f\u4e00\u540d\u4e94\u5341\u591a\u5c81\u7684\u534e\u88d4\u7537\u5b50\u30021\u670815\u65e5\u4ece\u6b66\u6c49\u98de\u62b5\u7f8e\u56fd\u7531\u6d1b\u6749\u77f6\u56fd\u9645\u673a\u573a\u901a\u9053\u5165\u5883\u65f6\uff0c\u5c31\u5df2\u7ecf\u51fa\u73b0\u4e86\u54b3\u55fd\u548c\u8f7b\u5fae\u53d1\u70ed\u7684\u75c7\u72b6\uff0c16\u65e5\u5c31\u88ab\u786e\u8bca\u4e3a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\uff0c1\u670819\u65e5\uff0c\u7531\u4e8e\u5df2\u7ecf\u51fa\u73b0\u4e864\u5929\u7684\u53d1\u70ed\u548c\u54b3\u55fd\uff0c\u52a0\u4e0a\u786e\u5b9e\u5b58\u5728\u6b66\u6c49\u65c5\u5c45\u53f2\uff0c\u4e8e\u662f\u4ed6\u6765\u5230\u4e86\u534e\u76db\u987f\u5dde\u65af\u8bfa\u970d\u7c73\u4ec0\u53bf\u7684\u6025\u8bca\u6240\u5c31\u8bca\u3002\u7f8e\u56fd\u7b2c\u4e8c\u4f8b\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u662f\u4e00\u540d\u516d\u5341\u591a\u5c81\u7684\u767d\u4eba\u5973\u6027\uff0c\u5979\u662f12\u6708\u4e0b\u65ec\u524d\u5f80\u6b66\u6c49\u65c5\u6e38\uff0c\u7ecf\u829d\u52a0\u54e5\u673a\u573a\u5165\u5883\uff0c\u968f\u540e\u4e5f\u88ab\u786e\u8bca\u3002\u4ed6\u4eec\u4e8c\u4eba\u90fd\u6beb\u65e0\u4f8b\u5916\u7684\u5728\u673a\u573a\u4e0e\u5927\u91cf\u4eba\u7fa4\u8fdb\u884c\u8fc7\u77ed\u6682\u4f46\u5341\u5206\u8fd1\u8ddd\u79bb\u7684\u63a5\u89e6\u3002<\/p>\n

\u4e0d\u8fc7\u672c\u4eba\u8ba4\u540c\u803f\u723d\u5728\u524d\u9762\u7684\u63cf\u8ff0\uff1a\u201c\u75c5\u6bd2\u6e90\u5934\u95ee\u9898\uff0c\u8fd9\u662f\u4e00\u4e2a\u79d1\u5b66\u7684\u95ee\u9898\uff0c\u9700\u8981\u542c\u53d6\u79d1\u5b66\u3001\u4e13\u4e1a\u7684\u610f\u89c1\u201c\u3002\u7f8e\u56fd\u6709\u65e0\u6d89\u53ca\u8fd9\u4e2a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff1f\u7b54\u6848\u5f88\u7b80\u5355\uff0c \u5bfb\u627e\u79d1\u5b66\u6587\u7ae0\u597d\u4e86\u3002\u8003\u8651\u5230\u5927\u591a\u6570\u56fd\u4eba\u4e0d\u61c2\u82f1\u6587\uff0c \u4e5f\u4e0d\u61c2\u4e13\u4e1a\uff0c \u4e5f\u53ef\u80fd\u4e0d\u4f1a\u7ffb\u5899\uff0c \u6211\u5c31\u8bf7\u6709\u5173\u4e13\u5bb6\u5e2e\u5fd9\uff0c \u627e\u51fa\u7ecf\u5178\u7684\u4e24\u7bc7\u6587\u7ae0\uff0c \u89e3\u91ca\u5e76\u90e8\u5206\u8bd1\u6210\u4e2d\u6587\uff0c \u770b\u770b\u75c5\u6bd2\u7684\u6e90\u5934\u95ee\u9898\uff0c \u5e0c\u671b\u803f\u723d\u548c\u89c2\u4f17\u90fd\u80fd\u591f\u770b\u7684\u660e\u767d\u3002<\/p>\n

\u5168\u7403\u9876\u7ea7\u7684\u79d1\u5b66\u6742\u5fd7\u300a\u81ea\u7136\u300b\u548c\u5176\u5b50\u520a\u300a\u81ea\u7136\u533b\u5b66\u300b\u7b49\uff0c\u5747\u662f\u4e25\u8c28\u7684\uff0c\u4e3a\u65e0\u6570\u79d1\u7814\u4eba\u5458\u5949\u4e3a\u81f3\u5b9d\u7684\u671f\u520a\u3002\u5728\u6570\u4ee5\u4e07\u8ba1\u7684\u6742\u5fd7\u4e2d\uff0c\u5176\u76f8\u5bf9\u6743\u5a01\uff0c\u5ba2\u89c2\u548c\u516c\u6b63\u7684\u7acb\u573a\uff0c\u957f\u671f\u6709\u76ee\u5171\u7779\u3002\u4e2d\u56fd\u79d1\u5b66\u5bb6\u4e5f\u4e00\u76f4\u5c06\u8bba\u6587\u53d1\u8868\u5728\u300a\u81ea\u7136\u300b\u7b49\u520a\u7269\u4e0a\uff0c\u89c6\u4e3a\u8363\u8000\u548c\u83b7\u5f97\u56fd\u5bb6\u5956\u52b1\u7684\u51ed\u8bc1\u3002\u6b66\u6c49\u75c5\u6bd2\u7814\u7a76\u6240\u77f3\u6b63\u4e3d\u548c\u845b\u884c\u4e49\u7b49\u4eba\u5206\u522b\u4e8e2013\u5e7410\u670830\u4eba\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7https:\/\/www.nature.com\/articles\/nature12711<\/a>\uff0c\u548c2015 \u5e7411\u67089\u65e5\u5728\u300a\u81ea\u7136\u533b\u5b66\u300b\u6742\u5fd7https:\/\/www.nature.com\/articles\/nm.3985<\/a>\u00a0\u4e0a\u53d1\u8868\u4e86\u91cd\u8981\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u6587\u7ae0\u3002\u4efb\u4f55\u4eba\u90fd\u53ef\u8bbf\u95ee\u8fd9\u4e24\u7bc7\u6587\u7ae0\u7f51\u5740\uff0c\u6ca1\u6709\u9650\u5236\u3002<\/p>\n

\u5148\u770b2013\u5e74\u7684\u300a\u81ea\u7136\u300b\u6742\u5fd7\uff0c \u7531\u845b\u884c\u4e49\u7b49\u4e09\u4eba\uff08\u6ce8\u4e3a*\uff09\u5b8c\u6210\uff0c\u6309\u60ef\u4f8b\u8d1f\u8d23\u4eba\u6392\u5728\u6700\u540e\uff0c \u540d\u4e3a\u901a\u8baf\u4f5c\u8005\u7684\u77f3\u6b63\u4e3d\u3002\u4e2d\u6587\u7ffb\u8bd1\u4e3a\uff1a\u201d\u5206\u79bb\u548c\u9274\u5b9a\u8428\u65af\u6837\u7684\u8759\u8760\u51a0\u72b6\u75c5\u6bd2\uff0c \u8be5\u75c5\u6bd2\u5e94\u7528ACE2\u53d7\u4f53\u201c\u3002\u6ce8\u610f\u76ee\u524d\u6d41\u884c\u7684\u6b66\u6c49\u80ba\u708e\u75c5\u6bd2\u76f4\u63a5\u653b\u51fb\u4eba\u7c7b\uff0c \u6b63\u662fACE2\u53d7\u4f53\u3002\u5728\u6458\u8981\u4e2d\uff0c\u8be5\u6587\u58f0\u79f0\u8759\u8760\u6765\u81ea\u4e91\u5357\uff0c\u800c\u5e94\u7528\u7684ACE2\u6765\u81ea\u4eba\u7c7b\u3002\u65b9\u6cd5\u4e2d\uff0c \u63d0\u5230\u4e86\u91cd\u7ec4\u75c5\u6bd2\u7684\u5206\u6790\uff08Recombination analysis\uff09\uff0c \u5e76\u6210\u4e3a\u5176\u4e2d\u7684\u5c0f\u6807\u9898\u3002\u867d\u7136\u6709\u5408\u4f5c\u8005\uff0c\u4f46\u6b66\u6c49\u75c5\u6bd2\u6240\u5360\u636e\u4e86\u5168\u90e8\u5de5\u4f5c\u768490%\u4ee5\u4e0a\uff0c\u5c24\u5176\u662f\u524d\u4e09\u4f4d\u548c\u6700\u540e\u4e00\u4f4d\u8d1f\u8d23\u7684\u77f3\u6b63\u4e3d\u3002<\/p>\n

\"IMG_1102.JPG\"<\/p>\n

 <\/p>\n

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor<\/strong><\/p>\n

Xing-Yi Ge1 *, Jia-Lu Li1 *, Xing-Lou Yang1 *, Aleksei A. Chmura2 , Guangjian Zhu2 , Jonathan H. Epstein2 , Jonna K. Mazet3 , Ben Hu1 , Wei Zhang1 , Cheng Peng1 , Yu-Ji Zhang1 , Chu-Ming Luo1 , Bing Tan1 , Ning Wang1 , Yan Zhu1 , Gary Crameri4 , Shu-Yi Zhang5 , Lin-Fa Wang4,6, Peter Daszak2 & Zheng-Li Shi<\/p>\n

 <\/p>\n

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\"IMG_1103.JPG\"<\/p>\n

 <\/p>\n

Nature\u5b98\u7f51\u539f\u6587:\u00a0https:\/\/www.nature.com\/articles\/nm.3985<\/a><\/p>\n

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence<\/h1>\n

1.Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 2. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 3. National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. 4. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. 5. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 6. Cystic Fibrosis Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 7. Institute for Research in Biomedicine, Bellinzona Institute of Microbiology, Zurich, Switzerland. 8. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. 9. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Received 12 June; accepted 8 October; published online 9 November 2015; corrected online 20 November 2015 (details online); doi:10.1038\/nm.3985<\/p>\n

 <\/p>\n

\u4e0b\u9762\u6458\u5f55\u90e8\u5206\u8282\u6bb5\uff0c \u53ef\u6e05\u6670\u7684\u770b\u89c1\u75c5\u6bd2\u7684\u8d77\u6e90\uff0c \u5371\u5bb3\u53ca\u6b66\u6c49\u75c5\u6bd2\u6240\u7684\u5177\u4f53\u8d21\u732e\u3002<\/p>\n

We consider viruses with the\u00a0SHC014 spike a potential threat owing to their ability to replicate in primary human airway cultures, the best available model for human disease. In addition, the observed pathogenesis in mice indicates a capacity for SHC014-containing viruses to cause disease in mammalian models, without RBD adaptation.<\/strong><\/p>\n

\u5728\u4eba\u7c7b\u547c\u5438\u9053\u7684\u590d\u5236\u548c\u75c5\u6bd2\u7684\u5371\u5bb3\u3002<\/p>\n

\u2026\u2026<\/p>\n

Together, the data confirm the ability of viruses with the SHC014 spike to infect human airway cells and underscore the potential threat of cross-species transmission of SHC014-CoV.<\/p>\n

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\u2026\u2026<\/p>\n

Overall, our approach has used metagenomics data to identify a potential threat posed by the circulating bat SARS-like CoV SHC014. Because of the ability of chimeric SHC014 viruses to replicate in human airway cultures, cause pathogenesis in vivo and escape current therapeutics, there is a need for both surveillance and improved therapeutics against circulating SARS-like viruses.<\/p>\n

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\u2026\u2026<\/p>\n

an HIV-based pseudovirus, prepared as previously described, and\u00a0examined on HeLa cells (Wuhan Institute of Virology) that expressed\u00a0ACE2<\/em>\u00a0orthologs<\/strong>. HeLa cells were grown in minimal essential medium (MEM) (Gibco, CA) supplemented with 10% FCS<\/p>\n

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\u2026\u2026<\/p>\n

Acknowledgment<\/p>\n

Experiments with the\u00a0full-length and chimeric SHC014 recombinant viruses<\/strong>\u00a0were initiated and performed before the GOF research funding pause and have since been reviewed and approved for continued study by the NIH.<\/p>\n

\u91cd\u7ec4\u75c5\u6bd2SHC014\u7684\u5b9e\u9a8c\u83b7\u5f97\u4e86\u7f8e\u56fdNIH\u7684\u6279\u51c6\u3002<\/p>\n

AUTHOR CONTRIBUTIONS<\/p>\n

\u2026\u2026X.-Y.G. performed pseudotyping experiments; K.D. generated structural figures and predictions; E.F.D. generated phylogenetic analysis; R.L.G. completed RNA analysis; S.H.R. provided primary HAE cultures; A.L. and W.A.M. provided critical monoclonal antibody reagents;\u00a0and Z.-L.S. provided SHC014 spike sequences and plasmids.\u00a0<\/strong>R.S.B. designed experiments and wrote manuscript.<\/p>\n

\u77f3\u6b63\u4e3d\u63d0\u4f9b\u4e86SHC014\u7684\u5e8f\u5217\u548c\u8d28\u7c92 \uff08\u57fa\u56e0\u5de5\u7a0b\u6216\u75c5\u6bd2\u91cd\u7ec4\u6280\u672f\u5fc5\u987b\u7528\u5230\u7684\u751f\u7269\u5e8f\u5217\u8f7d\u4f53\u3002\u8d28\u7c92\u8f7d\u4f53\u901a\u5e38\u5e26\u6709\u4e00\u4e2a\u6216\u4e00\u4e2a\u4ee5\u4e0a\u7684\u9009\u62e9\u6027\u6807\u8bb0\u57fa\u56e0\uff08\u5982\u6297\u751f\u7d20\u6297\u6027\u57fa\u56e0\uff09\u548c\u4e00\u4e2a\u4eba\u5de5\u5408\u6210\u7684\u542b\u6709\u591a\u4e2a\u9650\u5236\u6027\u5185\u5207\u9176\u8bc6\u522b\u4f4d\u70b9\u7684\u591a\u514b\u9686\u4f4d\u70b9\u5e8f\u5217\uff0c\u5e76\u53bb\u6389\u4e86\u5927\u90e8\u5206\u975e\u5fc5\u9700\u5e8f\u5217\uff0c\u4f7f\u5206\u5b50\u91cf\u5c3d\u53ef\u80fd\u51cf\u5c11\uff0c\u4ee5\u4fbf\u4e8e\u91cd\u7ec4\u57fa\u56e0\u5de5\u7a0b\u64cd\u4f5c\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u6ca1\u6709\u77f3\u63d0\u4f9b\u7684SHC014\u7684\u5e8f\u5217\u548c\u8d28\u7c92\uff0c \u672c\u7bc7\u8bba\u6587\u65e0\u6cd5\u5b8c\u6210\u6240\u6709\u7684\u5b9e\u9a8c\uff09\u3002<\/p>\n

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\u56de\u590d\u00a0|\u00a0<\/i>3<\/em><\/div>\n<\/td>\n
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\u56de\u590d\u00a0|\u00a0<\/i>4<\/em><\/div>\n<\/td>\n
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